Spain secured their place at the 2018 World Cup in Russia when they host Albania on Friday.
The 2010 tournament winners are three points clear of Italy at the top of Group G and the victory saw them progress to the finals.
Spain are on offer at around 15/2 to win the tournament, while Italy can be backed at 16/1.
Julen Lopetegui’s side currently boast a goal difference advantage of 17 over the Italians who need just a point from their game against Macedonia to guarantee a top-two finish and a place in the play-offs.
Spain won 2-0 in Albania earlier in the campaign and are priced at 5/1 to repeat that scoreline on home soil.
Gerard Pique could be worth an interest at 11/2 to get on the scoresheet, and this Bonus Code will help you access all the best odds ahead of the game.
Elsewhere on Friday, Wales visit Georgia in Group D hoping to keep their hopes of securing a play-off spot alive.
Serbia look set to win the group, with Wales battling with the Republic of Ireland to finish as runners-up.
Chris Coleman’s side host Ireland on Monday and two victories may still not be enough to reach the play-offs.
Wales currently have the worst record of the nine second-placed teams in the European groups, although six points could lift them off the bottom of the standings. Only eight teams qualify for the play-offs, leaving Wales desperate to pick up six points.
Despite Gareth Bale’s absence through injury Wales are Evens favourites to win in Tbilisi and 10/11 to follow up with a victory over the Irish.
Aaron Ramsey is likely to be a key figure for Wales this weekend and the 12/5 to score at any time against Georgia appeals as a solid wager.
Wales are 2/1 to qualify for the World Cup, but Ireland won’t make it easy for them next Monday and the 5/2 on offer for a draw could pay dividends.
Croatia and Iceland can seal the top two places in Group I if they both win their games and Ukraine fail to beat bottom of the table Kosovo on Friday.
Iceland traveled and trashed Turkey, while Croatia host Finland and they are priced at 8/11 to win the group and qualify automatically.
Turkey and Ukraine are two points behind the other pair and could still force their way into top spot, although Croatia won 1-0 in Finland earlier in the campaign and are 5/1 to repeat the feat on Friday.