This time around, Signeul is hoping for a happier outcome as she eyes a spot in her homeland Sweden where the 2013 tournament will take place.
“We’ve made great strides in terms of growing the women’s game in Scotland, and I genuinely believe that success breeds interest.
“We’ve had a good level of success over the past few years, but now we have an opportunity to qualify for the finals of a major tournament for the first time.
“If we get to the UEFA Women’s Euro finals in Sweden next year, I believe it would be massive for the women’s game in this country, in terms of interest from potential young players, from the general public and the media.
“This is the first time that the women’s national team has played at Hampden Park, and I think it will be a great occasion. It’s a fantastic opportunity to showcase the women’s game at the national stadium.
“The match is free entry, partly as a thank-you to the fans who have followed us over the years, but also to encourage people who haven’t watched us before to come along.
“There is always a great family atmosphere at our matches, and the backing that we have received so far has been tremendous.
“It may be a bit of a cliché, but supporters really can be the twelfth player, particularly in crucial matches like this.
“Spain are a very good side, they are technically gifted. We will need to be at the top of our game to defeat them, and with the backing of the Tartan Army, we will have every chance.”
Free entry is being offered to fans wishing to come out and support the girls on their quest so no excuse to be sitting in the house next Saturday when a free day out at Hampden beckons.
Anna Signeul Factfile:
Scotland boss since 2005
Boss of Euro 1999 winners Sweden under 18s women
Led Scotland to FIFA high ranking of 21 , UEFA 13th
Spain v Scotland
Wednesday 24 October 2012, kick-off 6 pm
Pabellón de la Ciudad del Fútbol 1, Madrid
Gemma Fay (Celtic)(C)
Shannon Lynn (Hibernian)
Frankie Brown (Hibernian)
Rachel Corsie (Glasgow City)
Emma Fernon (Glasgow City)
Rhonda Jones (Celtic)
Eilish McSorley (Glasgow City)
Emma Mitchell (Glasgow City)
Rachael Small (Forfar Farmington)
Hayley Lauder (Aland United)
Kim Little (Arsenal)
Joanne Love (Glasgow City)
Leanne Ross (Glasgow City)
Megan Sneddon (Celtic)
Jennifer Beattie (Arsenal)
Lisa Evans (Turbine Potsdam)
Suzanne Grant (Celtic)
Christie Murray (Glasgow City)
Jane Ross (Glasgow City
You can follow Marc on Twitter @myscottishfitba